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Ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate

  • CAS No. 1220968-24-0

  • Cat. No. CS-0035955
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate|CS-0035955

Structure of 1220968-24-0

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General Information

  • CAS No. 1220968-24-0
  • Cat. No. CS-0035955
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₃BN₂O₄
  • Molecular Weight 294.15
  • Synonym(s) ethyl 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]propanoate
  • SMILES CCOC(=O)C(C)N1C=C(C=N1)B2OC(C)(C)C(C)(C)O2

Description

Ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate features a boronate ester group enabling reliable Suzuki-Miyaura coupling. The pyrazole core imparts stability and regioselectivity in cross-coupling reactions. This bench-stable reagent integrates efficiently into complex molecule assembly workflows.

Application

Ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate serves as a versatile boron-containing building block for palladium-catalyzed cross-coupling reactions. The pyrazole core provides stability and orthogonal reactivity, while the boronate ester enables efficient Suzuki-Miyaura coupling. This compound exhibits excellent bench stability, simplifies purification, and functions reliably in diverse synthetic workflows for constructing biologically relevant heterocyclic scaffolds and functionalized alkyl chains.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   62.58
  • LogP   1.3064
  • H_Acceptors   6
  • H_Donors   0
  • Rotatable_Bonds   4

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