Lot numbers can be found on the outside label of a product:
2-Chloro-4-(pyridin-3-yl)pyrimidine
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CAS No. 483324-01-2
- Cat. No. CS-0187828
- Purity≥98%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 483324-01-2
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General Information
- CAS No. 483324-01-2
- Cat. No. CS-0187828
- Purity ≥98%
- MDL No. None
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₆ClN₃
- Molecular Weight 191.62
- Synonym(s) 4-(3-Pyridyl)-2-chloropyrimidine
- SMILES C1=CC(=CN=C1)C2=NC(=NC=C2)Cl
Description
2-Chloro-4-(pyridin-3-yl)pyrimidine serves as a key heterocyclic scaffold in medicinal chemistry, integrating a chlorine electrophile with a pyridyl-directed electron-deficient core. This configuration enables efficient cross-coupling reactions and facilitates the construction of complex molecular architectures under mild conditions.
Application
2-Chloro-4-(pyridin-3-yl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via Pd-catalyzed cross-coupling reactions. The pyridyl and chloropyrimidine moieties offer orthogonal reactivity, facilitating sequential functionalization. Bench-stable and readily purified, it functions as a key intermediate in the synthesis of kinase inhibitors and other bioactive molecules.
Synthesis
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Route1
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3934-20-1 -
In-stock
1692-25-7 - ~73%
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In-stock
483324-01-2
References
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ZHANG, Dawei Patent: WO2011/8788 A1, 2011 ; Location in patent: Page/Page column 28-29 ; WO 2011/008788 A1
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Route2
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897031-20-8 - ~57%
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In-stock
483324-01-2
References
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Anli, Huang; Xing, Liu; Zelikovitch, Lior; Kaspi, Joseph Patent: US2006/149061 A1, 2006 ; Location in patent: Page/Page column 8 ;
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References
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Bursavich, Matthew G.; Lombardi, Sabrina; Gilbert, Adam M. Organic Letters, 2005 , vol. 7, # 19 p. 4113 - 4116
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 38.67
- LogP 2.192
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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