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CS-W001157 4
Total: USD 88.00

1-(2,5-Dimethoxyphenyl)ethanone

  • CAS No. 1201-38-3

  • Cat. No. CS-0020017
  • Purity≥98%
  • MDL No.MFCD00008728

*For research and further manufacturing use only, not for direct human use.

1-(2,5-Dimethoxyphenyl)ethanone|CS-0020017

Structure of 1201-38-3

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General Information

  • CAS No. 1201-38-3
  • Cat. No. CS-0020017
  • Purity ≥98%
  • MDL No. MFCD00008728
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂O₃
  • Molecular Weight 180.20
  • Synonym(s) Methyl 2,5-dimethoxyphenyl ketone; NSC 62094; Ethanone,1-(2,5-dimethoxyphenyl)-
  • SMILES CC(C1=CC(OC)=CC=C1OC)=O

Description

1-(2,5-Dimethoxyphenyl)ethanone features a benzene ring bearing two methoxy groups at the 2 and 5 positions, flanked by a ketone-substituted ethyl side chain. This electron-rich aromatic system integrates readily into synthetic routes requiring polarizable, bench-stable aryl ketones. The para-like substitution pattern enhances regioselective reactivity in electrophilic processes.

Application

1-(2,5-Dimethoxyphenyl)ethanone serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive scaffolds through standard functional group manipulations. Its bench-stable aryl ketone functionality tolerates diverse reaction conditions, facilitating nucleophilic additions, reductions, and coupling reactions. The 2,5-dimethoxy substitution pattern enhances solubility and provides orthogonal handles for further derivatization, making it a practical choice for synthetic campaigns targeting complex heterocycles and pharmaceutical intermediates.

Synthesis

  • Route1
    • 1-(2,5-Dimethoxyphenyl)ethanol|CS-0154127
      41038-40-8
    • ~89%
    • In-stock
      1-(2,5-Dimethoxyphenyl)ethanone|CS-0020017
      1201-38-3

    References

    • Oded, Kobi; Musa, Sanaa; Gelman, Dmitri; Blum, Jochanan Catalysis Communications, 2012 , vol. 20, p. 68 - 70
  • Route2
    • null|null
      108-24-7
    • 1,4-Dimethoxybenzene, 99%|CS-1269050
      150-78-7
    • ~68%
    • In-stock
      1-(2,5-Dimethoxyphenyl)ethanone|CS-0020017
      1201-38-3

    References

    • Hosseini-Sarvari, Mona; Safary, Ensieh Journal of Sulfur Chemistry, 2011 , vol. 32, # 5 p. 463 - 473
  • Route3
    • null|null
      75-36-5
    • 1,4-Dimethoxybenzene, 99%|CS-1269050
      150-78-7
    • ~98%
    • In-stock
      1-(2,5-Dimethoxyphenyl)ethanone|CS-0020017
      1201-38-3

    References

    • Werner, Georg; Butenschoen, Holger European Journal of Organic Chemistry, 2012 , # 16 p. 3132 - 3141

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   1.9064
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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