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CS-W001157 4
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1-(2-Methoxy-4-methylphenyl)ethanone

  • CAS No. 35633-35-3

  • Cat. No. CS-0375165
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(2-Methoxy-4-methylphenyl)ethanone|CS-0375165

Structure of 35633-35-3

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General Information

  • CAS No. 35633-35-3
  • Cat. No. CS-0375165
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂O₂
  • Molecular Weight 164.20
  • Synonym(s) 2'-Methoxy-4'-methylacetophenone
  • SMILES O=C(C)C1=CC=C(C)C=C1OC

Description

1-(2-Methoxy-4-methylphenyl)ethanone features a benzene ring bearing a methoxy group at the ortho position and a methyl substituent at the para position, integrated with a ketone-linked ethyl side chain. This electron-rich aryl ketone serves as a key intermediate in pharmaceutical synthesis, offering enhanced solubility and stability under standard bench conditions.

Application

1-(2-Methoxy-4-methylphenyl)ethanone serves as a versatile aryl ketone building block for medicinal chemistry and process synthesis. Its structure enables direct functionalization at the aromatic ring and compatibility with standard coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig protocols. The methyl and methoxy substituents provide moderate electron-donating character, enhancing reactivity in electrophilic substitution. Bench-stable and readily purified by recrystallization, it functions effectively in multistep syntheses of bioactive scaffolds and API intermediates.

Synthesis

  • Route1
    • In-stock
      2'-Hydroxy-4'-methylacetophenone|CS-0019286
      6921-64-8
    • null|null
      77-78-1
    • ~10%
    • In-stock
      1-(2-Methoxy-4-methylphenyl)ethanone|CS-0375165
      35633-35-3

    References

    • Petit, Laurent; Zard, Samir Z. Chemical Communications, 2010 , vol. 46, # 28 p. 5148 - 5150
  • Route2
    • In-stock
      2'-Hydroxy-4'-methylacetophenone|CS-0019286
      6921-64-8
    • null|null
      74-88-4
    • ~90%
    • In-stock
      1-(2-Methoxy-4-methylphenyl)ethanone|CS-0375165
      35633-35-3

    References

    • Montiel, Luisa E.; Zepeda, L. Gerardo; Tamariz, Joaquin Helvetica Chimica Acta, 2010 , vol. 93, # 7 p. 1261 - 1273
  • Route3
    • null|null
      122-46-3
    • ~%
    • In-stock
      1-(2-Methoxy-4-methylphenyl)ethanone|CS-0375165
      35633-35-3

    References

    • Harrowven, David C.; Lucas, Matthew C.; Howes, Peter D. Tetrahedron, 1999 , vol. 55, # 4 p. 1187 - 1196

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.20622
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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