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CS-W001157 4
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2-Fluoro-6-methylpyridin-4-amine

  • CAS No. 1622844-16-9

  • Cat. No. CS-0159873
  • Purity≥97%
  • MDL No.MFCD28055231
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-6-methylpyridin-4-amine|CS-0159873

Structure of 1622844-16-9

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Description

2-Fluoro-6-methylpyridin-4-amine features a strategically positioned fluorine atom and methyl group on the pyridine ring, delivering enhanced electron-withdrawing character and improved metabolic stability. This configuration enables efficient coupling in cross-coupling reactions and facilitates incorporation into bioactive scaffolds requiring moderate lipophilicity and targeted electronic tuning.

Application

2-Fluoro-6-methylpyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through palladium-catalyzed cross-coupling reactions. Its fluorine and amino groups provide orthogonal reactivity for late-stage functionalization, while the methyl group enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and compatibility with standard purification methods, facilitating integration into multi-step synthetic sequences for API development.

General Information

  • CAS No. 1622844-16-9
  • Cat. No. CS-0159873
  • Purity ≥97%
  • MDL No. MFCD28055231
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇FN₂
  • Molecular Weight 126.13
  • Synonym(s) 4-Amino-2-fluoro-6-methylpyridine
  • SMILES NC1=CC(F)=NC(C)=C1

Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.11132
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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