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CS-W001157 4
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4-Amino-2-fluoropyridine

  • CAS No. 18614-51-2

  • Cat. No. CS-W007675
  • Purity≥98%
  • MDL No.MFCD03095284

*For research and further manufacturing use only, not for direct human use.

4-Amino-2-fluoropyridine|CS-W007675

Structure of 18614-51-2

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General Information

  • CAS No. 18614-51-2
  • Cat. No. CS-W007675
  • Purity ≥98%
  • MDL No. MFCD03095284
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅FN₂
  • Molecular Weight 112.11
  • Synonym(s) 2-fluoro-4-amino pyridine
  • SMILES NC1=CC(=NC=C1)F

Description

4-Amino-2-fluoropyridine is a fluorinated heterocyclic building block featuring a strategically positioned amino group and electron-withdrawing fluorine. This combination enables enhanced reactivity in cross-coupling and electrophilic substitution reactions, while maintaining bench-stable handling properties under standard conditions.

Application

4-Amino-2-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized pyridine scaffolds. Its ortho-fluoro and amino groups facilitate palladium-catalyzed cross-coupling reactions and electrophilic substitution processes, offering high regioselectivity. The compound exhibits excellent bench stability and compatibility with diverse reaction conditions, simplifying purification and integration into multi-step syntheses of bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   0.8029
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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