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CS-W001157 4
Total: USD 88.00

(S)-1-Boc-3,4-dihydro-2H-quinoline-2-carboxylic acid

  • CAS No. 1187933-14-7

  • Cat. No. CS-0005421
  • Purity≥98%
  • MDL No.MFCD04115278
  • HazMat Fee +

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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

(S)-1-Boc-3,4-dihydro-2H-quinoline-2-carboxylic acid|CS-0005421

Structure of 1187933-14-7

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Description

(S)-1-Boc-3,4-dihydro-2H-quinoline-2-carboxylic acid features a chiral quinoline core with a bench-stable Boc-protected carboxylic acid moiety, enabling direct incorporation into peptide-like scaffolds. The dihydroquinoline ring system offers enhanced solubility and reduced oxidation susceptibility compared to aromatic analogs, facilitating use in asymmetric synthesis and medicinal chemistry applications.

Application

(S)-1-Boc-3,4-dihydro-2H-quinoline-2-carboxylic acid serves as a versatile chiral building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. The Boc-protected amine enables orthogonal functionalization, while the dihydroquinoline core supports diverse transformations including hydrogenation, electrophilic substitution, and coupling reactions. Bench-stable and readily purified, it facilitates efficient access to complex scaffolds in medicinal chemistry campaigns.

General Information

  • CAS No. 1187933-14-7
  • Cat. No. CS-0005421
  • Purity ≥98%
  • MDL No. MFCD04115278
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₉NO₄
  • Molecular Weight 277.32
  • Synonym(s) (s)-1-(Tert-butoxycarbonyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid
  • SMILES O=C(OC(C)(C)C)N(C(C=CC=C1)=C1CC2)[C@@H]2C(O)=O

Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.8275
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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