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CS-W001157 4
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4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine hydrochloride

  • CAS No. 1175273-62-7

  • Cat. No. CS-0179025
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine hydrochloride|CS-0179025

Structure of 1175273-62-7

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General Information

  • CAS No. 1175273-62-7
  • Cat. No. CS-0179025
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₅BClN₃O₂
  • Molecular Weight 313.63
  • Synonym(s) 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]piperidine,hydrochloride
  • SMILES Cl.N1=CC(=CN1C2CCNCC2)B3OC(C)(C)C(O3)(C)C

Synthesis

  • Route1
    • tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate Crizotinib  Impurity|CS-0229069
      877399-74-1
    • ~99%
    • In-stock
      4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine hydrochloride|CS-0179025
      1175273-62-7

    References

    • OSI PHARMACEUTICALS, LLC; HOMBERGER, Keith, R.; BERGER, Dan, M.; CHEN, Xin; CREW, Andrew, P.; DONG, Hanqing; KLEINBERG, Andrew; LI, An-Hu; MA, Lifu; MULVIHILL, Mark, J.; PANICKER, Bijoy; SIU, Kam, W.; STEINIG, Arno, G.; TARRANT, James, G.; WANG, Jing; WENG, Qinghua; SANGEM, Rajaram; GUPTA, Ramesh, C. Patent: WO2011/100502 A1, 2011 ; Location in patent: Page/Page column 42 ; WO 2011/100502 A1
  • Route2
    • null|null
      109384-19-2
    • ~%
    • In-stock
      4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine hydrochloride|CS-0179025
      1175273-62-7

    References

    • HUTCHISON MEDIPHARMA LIMITED; Su, Wei-Guo; Deng, Wei; Ji, Jianguo Patent: US2014/121200 A1, 2014 ;
  • Route3
    • null|null
      141699-59-4
    • ~%
    • In-stock
      4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine hydrochloride|CS-0179025
      1175273-62-7

    References

    • HUTCHISON MEDIPHARMA LIMITED; Su, Wei-Guo; Deng, Wei; Ji, Jianguo Patent: US2014/121200 A1, 2014 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.31
  • LogP   1.5286
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   2

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