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CS-W001157 4
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1-(4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidin-1-yl)ethan-1-one

  • CAS No. 1092563-66-0

  • Cat. No. CS-0132201
  • Molecule weight319.21
  • Purity≥97%
  • MDL No.MFCD18383262

*For research and further manufacturing use only, not for direct human use.

1-(4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidin-1-yl)ethan-1-one|CS-0132201

Structure of 1092563-66-0

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General Information

  • CAS No. 1092563-66-0
  • Cat. No. CS-0132201
  • Purity ≥97%
  • MDL No. MFCD18383262
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₆BN₃O₃
  • Molecular Weight 319.21
  • Synonym(s) 1-{4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidin-1-yl}ethan-1-one
  • SMILES CC(N1CCC(N2N=CC(B3OC(C)(C)C(C)(C)O3)=C2)CC1)=O

Description

This boronate-functionalized pyrazole-piperidine ketone integrates seamlessly into Suzuki-Miyaura cross-coupling reactions. The tetramethylboronate moiety enables efficient, palladium-catalyzed bond formation under mild conditions, while the sterically hindered piperidine scaffold enhances solubility and stability. Designed for streamlined synthesis of complex heterocyclic architectures in medicinal chemistry and materials science applications.

Application

1-(4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidin-1-yl)ethan-1-one serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The tetramethyl-1,3,2-dioxaborolane moiety enables stable, room-temperature handling and high functional group tolerance. It facilitates efficient C–C bond formation with aryl and heteroaryl halides, enabling rapid diversification of pyrazole-containing piperidine scaffolds in medicinal chemistry and materials synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   56.59
  • LogP   1.3657
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   2

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