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CS-W001157 4
Total: USD 88.00

1-(Difluoromethyl)-1H-pyrazol-4-amine

  • CAS No. 1174309-16-0

  • Cat. No. CS-0052829
  • Purity≥97%
  • MDL No.MFCD11558117

*For research and further manufacturing use only, not for direct human use.

1-(Difluoromethyl)-1H-pyrazol-4-amine|CS-0052829

Structure of 1174309-16-0

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General Information

  • CAS No. 1174309-16-0
  • Cat. No. CS-0052829
  • Purity ≥97%
  • MDL No. MFCD11558117
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅F₂N₃
  • Molecular Weight None
  • Synonym(s) 1H-Pyrazol-4-amine, 1-(difluoromethyl)-
  • SMILES NC1=CN(N=C1)C(F)F

Description

1-(Difluoromethyl)-1H-pyrazol-4-amine features a difluoromethyl group appended to a pyrazole scaffold, delivering enhanced metabolic stability and favorable lipophilicity. This electron-deficient heterocycle integrates readily into bioactive molecules, serving as a strategic isostere for carbonyl or methyl groups in medicinal chemistry applications.

Application

1-(Difluoromethyl)-1H-pyrazol-4-amine serves as a versatile building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable difluoromethyl group at the pyrazole C1 position. Its amine functionality facilitates straightforward derivatization via coupling reactions, while the difluoromethyl moiety enhances lipophilicity and bioavailability. The compound exhibits good bench stability and is compatible with standard synthetic protocols, making it valuable for constructing diverse heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H314-H335
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   0.8604
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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