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CS-W001157 4
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(R)-Ph-Pyox

  • CAS No. 117408-99-8

  • Cat. No. CS-0086892
  • Purity≥97%
  • MDL No.MFCD28100924

*For research and further manufacturing use only, not for direct human use.

(R)-Ph-Pyox|CS-0086892

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General Information

  • CAS No. 117408-99-8
  • Cat. No. CS-0086892
  • Purity ≥97%
  • MDL No. MFCD28100924
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₂N₂O
  • Molecular Weight 224.26
  • Synonym(s) (R)-4-Phenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole
  • SMILES C1(C2=N[C@H](C3=CC=CC=C3)CO2)=NC=CC=C1

Description

(R)-Ph-Pyox features a chiral pyridine-oxazoline scaffold with defined stereochemistry, enabling precise asymmetric induction in transition metal catalysis. This bench-stable ligand integrates seamlessly into palladium and nickel systems, delivering high enantioselectivity in cross-coupling reactions under standard conditions.

Application

(R)-Ph-Pyox serves as a robust chiral ligand in asymmetric catalysis, enabling high enantioselectivity in palladium-catalyzed cross-coupling reactions. Its pyridine-oxazoline architecture provides strong metal coordination and excellent stereocontrol, facilitating the synthesis of enantiomerically enriched biaryl and heteroaryl scaffolds. The ligand exhibits bench stability, ease of handling, and compatibility with diverse functional groups, making it a practical choice for scalable asymmetric synthesis in medicinal chemistry and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   34.48
  • LogP   2.5997
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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