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CS-W001157 4
Total: USD 88.00

(S)-Ph-Pyox

  • CAS No. 153880-57-0

  • Cat. No. CS-0086899
  • Purity≥97%
  • MDL No.MFCD28015870

*For research and further manufacturing use only, not for direct human use.

(S)-Ph-Pyox|CS-0086899

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General Information

  • CAS No. 153880-57-0
  • Cat. No. CS-0086899
  • Purity ≥97%
  • MDL No. MFCD28015870
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₂N₂O
  • Molecular Weight 224.26
  • Synonym(s) Pyridine, 2-[(4S)-4,5-dihydro-4-phenyl-2-oxazolyl]-
  • SMILES C1(C2=N[C@@H](C3=CC=CC=C3)CO2)=NC=CC=C1

Description

(S)-Ph-Pyox is a chiral pyridoxal-derived scaffold featuring a stereogenic center at the alpha position. This configuration enables selective asymmetric synthesis in catalytic transformations. The molecule integrates a phenyl group and a pyridoxal-like core, offering enhanced stability and tunable reactivity under physiological conditions. Its defined stereochemistry facilitates precise control in enantioselective reactions.

Application

(S)-Ph-Pyox serves as a highly effective chiral ligand in palladium-catalyzed asymmetric cross-coupling reactions, enabling enantioselective C–C bond formation with broad functional group tolerance. Its robust bench stability and ease of handling facilitate reproducible synthesis of chiral biaryl motifs, commonly encountered in pharmaceutical intermediates and agrochemicals.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   34.48
  • LogP   2.5997
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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