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CS-W001157 4
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1-(2-Bromoethyl)-2-pyrrolidinone

  • CAS No. 117018-99-2

  • Cat. No. CS-0040579
  • Purity≥95%
  • MDL No.MFCD09804536

*For research and further manufacturing use only, not for direct human use.

1-(2-Bromoethyl)-2-pyrrolidinone|CS-0040579

Structure of 117018-99-2

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General Information

  • CAS No. 117018-99-2
  • Cat. No. CS-0040579
  • Purity ≥95%
  • MDL No. MFCD09804536
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀BrNO
  • Molecular Weight 192.05
  • Synonym(s) 1-(2-Bromoethyl)pyrrolidin-2-one
  • SMILES O=C1N(CCBr)CCC1

Description

1-(2-Bromoethyl)-2-pyrrolidinone is a reactive electrophilic building block featuring a bromoethyl side chain tethered to a pyrrolidinone ring. This configuration enables direct conjugation with nucleophiles, facilitating efficient incorporation into bioconjugates and polymer architectures under mild conditions. The molecule exhibits excellent stability during storage and compatibility with diverse reaction media.

Application

1-(2-Bromoethyl)-2-pyrrolidinone serves as a versatile bifunctional building block, enabling efficient construction of nitrogen-containing heterocycles and pharmaceutical intermediates. The bromo group facilitates nucleophilic substitution reactions, while the pyrrolidinone ring provides a stable, polar scaffold with favorable solubility and functional group tolerance. Its bench-stable nature and compatibility with standard coupling protocols make it well-suited for use in medicinal chemistry campaigns and process-scale synthesis.

Synthesis

  • Route1

    References

    • Lisina, N. I.; Chernov, G. A.; Bizunov, Yu. M.; Emel'yanov, V. I.; Knunyants, I. L. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 6 p. 472 - 476 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 6 p. 705 - 710
  • Route2
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    • In-stock
      1-(2-Bromoethyl)-2-pyrrolidinone|CS-0040579
      117018-99-2

    References

    • Langmuir, , vol. 28, # 18 p. 7174 - 7181

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   1.0037
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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