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CS-W001157 4
Total: USD 88.00

2-fluoro-6-methoxypyridine

  • CAS No. 116241-61-3

  • Cat. No. CS-W000805
  • Molecule weight127.12
  • Purity≥98%
  • MDL No.MFCD09998161

*For research and further manufacturing use only, not for direct human use.

2-fluoro-6-methoxypyridine|CS-W000805

Structure of 116241-61-3

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General Information

  • CAS No. 116241-61-3
  • Cat. No. CS-W000805
  • Purity ≥98%
  • MDL No. MFCD09998161
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FNO
  • Molecular Weight 127.12
  • Synonym(s) None
  • SMILES COc1cccc(F)n1

Description

2-Fluoro-6-methoxypyridine features a fluorinated pyridine core with a methoxy group at the para position, delivering enhanced electron-withdrawing character and improved metabolic stability. This configuration enables selective coupling in cross-coupling reactions and facilitates incorporation into bioactive scaffolds requiring polar, electron-deficient heterocycles.

Application

2-Fluoro-6-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C2 position via nucleophilic substitution due to the electron-withdrawing fluorine. The methoxy group at C6 enhances solubility and modulates electronic properties, while the pyridine core provides a robust scaffold for constructing bioactive heterocycles. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions facilitate efficient synthesis of pharmaceutical intermediates.

Synthesis

  • Route1
    • null|null
      1628-89-3
    • ~%
    • In-stock
      2-fluoro-6-methoxypyridine|CS-W000805
      116241-61-3

    References

    • Journal of Organic Chemistry, , vol. 54, # 7 p. 1726 - 1731
  • Route2
    • null|null
      116241-56-6
    • ~73%
    • In-stock
      2-fluoro-6-methoxypyridine|CS-W000805
      116241-61-3

    References

    • Umemoto, Teruo; Tomizawa, Ginjiro Journal of Organic Chemistry, 1989 , vol. 54, # 7 p. 1726 - 1731

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.2293
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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