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Structure of 116241-61-3
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2-Fluoro-6-methoxypyridine features a fluorinated pyridine core with a methoxy group at the para position, delivering enhanced electron-withdrawing character and improved metabolic stability. This configuration enables selective coupling in cross-coupling reactions and facilitates incorporation into bioactive scaffolds requiring polar, electron-deficient heterocycles.
2-Fluoro-6-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C2 position via nucleophilic substitution due to the electron-withdrawing fluorine. The methoxy group at C6 enhances solubility and modulates electronic properties, while the pyridine core provides a robust scaffold for constructing bioactive heterocycles. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions facilitate efficient synthesis of pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H226-H315-H319-H335
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
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Lot numbers can be found on the outside label of a product: