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CS-W001157 4
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2-Oxa-6-azaspiro[3.3]heptane oxalate

  • CAS No. 1159599-99-1

  • Cat. No. CS-B1362
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Oxa-6-azaspiro[3.3]heptane oxalate|CS-B1362

Structure of 1159599-99-1

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General Information

  • CAS No. 1159599-99-1
  • Cat. No. CS-B1362
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₁NO₅
  • Molecular Weight 189.17
  • Synonym(s) 2-oxa-6-azaspiro[3.3]heptane, hemioxalate salt
  • SMILES O=C(O)C(O)=O.C12(COC2)CNC1

Description

2-Oxa-6-azaspiro[3.3]heptane oxalate is a rigid, bicyclic heterocyclic scaffold featuring a spiro-linked oxazole and azetidine core. This configuration imparts enhanced stability and defined spatial orientation, making it valuable for probing stereochemical effects in medicinal chemistry. The oxalate counterion improves solubility and handling under standard conditions.

Application

2-Oxa-6-azaspiro[3.3]heptane oxalate serves as a stable, bench-friendly spirocyclic building block featuring a constrained 7-membered ring system with orthogonal heteroatoms. It enables efficient access to complex nitrogen- and oxygen-containing scaffolds through standard functional group manipulations. The oxalate salt enhances solubility and purification ease, facilitating its use in medicinal chemistry campaigns and catalytic transformations requiring rigid, conformationally restricted intermediates.

Synthesis

  • Route1

    References

    • Chen, Xing-Xiu; Gao, Feng; Wang, Qi; Huang, Xing; Wang, Dan Fitoterapia, 2014 , vol. 92, p. 111 - 115
  • Route2

    References

    • Fitoterapia, , vol. 92, p. 111 - 115
  • Route3

    References

    • Fitoterapia, , vol. 92, p. 111 - 115

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   95.86
  • LogP   -1.2382
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   0

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