(3-Bromo-2,5-difluorophenyl)methanol

Name: (3-Bromo-2,5-difluorophenyl)methanol
Brand: ChemScene
Availability: InStock
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CAS No. 1159186-56-7
Cat. No. CS-W007146
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(3-Bromo-2,5-difluorophenyl)methanol|CS-W007146

Structure of 1159186-56-7

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General Information

CAS No. 1159186-56-7
Cat. No. CS-W007146
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅BrF₂O
Molecular Weight 223.02
Synonym(s) 3-Bromo-2,5-difluorobenzyl alcohol
SMILES OCC1=CC(F)=CC(Br)=C1F

Description

This boronate-bearing arylmethanol features a trifluorinated benzene core with orthogonal functional handles, enabling direct coupling in cross-coupling protocols. The bromo group facilitates Pd-catalyzed transformations, while the hydroxymethyl moiety offers downstream derivatization potential under standard conditions.

Application

(3-Bromo-2,5-difluorophenyl)methanol serves as a versatile building block for Suzuki-Miyaura and Negishi coupling reactions, enabling efficient construction of biaryl and heterocyclic scaffolds. The pendant hydroxymethyl group facilitates derivatization to esters, ethers, or amides, while the bromo and difluoro substituents offer orthogonal functional handles for sequential transformations. Bench-stable and compatible with standard reaction conditions, it supports scalable synthesis in medicinal chemistry and materials science applications.

Synthesis

Route1
- 112279-62-6
- ~%
- In-stock
  
  1159186-56-7
References
- CELLZOME LIMITED; OXENFORD, Sally; HOBSON, Andrew; OLIVER, Kathryn; RATCLIFFE, Andrew; RAMSDEN, Nigel Patent: WO2013/17479 A1, 2013 ; WO 2013/017479 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 20.23
LogP 2.2196
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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(3-Bromo-2,5-difluorophenyl)methanol

CAS No. 1159186-56-7

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