Lot numbers can be found on the outside label of a product:
2-(Tritylthio)acetic acid
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CAS No. 34914-36-8
- Cat. No. CS-0161576
- Purity≥98%
- MDL No.MFCD00386069
*For research and further manufacturing use only, not for direct human use.
Structure of 34914-36-8
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General Information
- CAS No. 34914-36-8
- Cat. No. CS-0161576
- Purity ≥98%
- MDL No. MFCD00386069
- Storage 4°C, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₂₁H₁₈O₂S
- Molecular Weight 334.43
- Synonym(s) Acetic acid, 2-[(triphenylmethyl)thio]-
- SMILES O=C(O)CSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3
Description
2-(Tritylthio)acetic acid features a robust trityl-protected thiol group enabling stable, orthogonal protection in synthetic workflows. This moiety integrates seamlessly into peptide and oligonucleotide conjugations, offering reliable deprotection under mild acidic conditions. The compound exhibits excellent solubility in organic solvents and maintains stability during storage, facilitating its use in complex molecule assembly.
Application
2-(Tritylthio)acetic acid serves as a robust sulfur protecting group for thiols, enabling selective deprotection under mild acidic conditions. Its trityl moiety provides excellent steric shielding and enhances solubility in organic media, facilitating purification and handling. The compound functions reliably in peptide synthesis and medicinal chemistry workflows, where orthogonal protection strategies are required.
Synthesis
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Route1
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76-83-5 -
68-11-1
- ~97%
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In-stock
34914-36-8
References
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Ding, Rui; He, Yong; Xu, Jingli; Liu, Hang; Wang, Xiao; Feng, Man; Qi, Chuanmin; Zhang, Junbo; Peng, Cheng Medicinal Chemistry Research, 2012 , vol. 21, # 4 p. 523 - 530
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Route2
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83544-05-2 - ~99%
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In-stock
34914-36-8
References
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Liu, Show-Wen; Lin, Cheng-Hsien; Lin, Tsyh-Lang; Hsu, Cheng-Fang Patent: US2011/40123 A1, 2011 ; Location in patent: Page/Page column 2; Sheet 4 ;
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Route3
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29167-19-9
- ~92%
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In-stock
34914-36-8
References
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ABSOLUTE SCIENCE, INC. Patent: WO2009/45761 A1, 2009 ; Location in patent: Page/Page column 65 ; WO 2009/045761 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335-H413
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 37.3
- LogP 4.7963
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 6
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Key Words
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