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CS-W001157 4
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7-bromo-2-chlorothieno[3,2-d]pyrimidine

  • CAS No. 1152475-42-7

  • Cat. No. CS-W000262
  • Molecule weight249.52
  • Purity≥98%
  • MDL No.MFCD13193398

*For research and further manufacturing use only, not for direct human use.

7-bromo-2-chlorothieno[3,2-d]pyrimidine|CS-W000262

Structure of 1152475-42-7

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General Information

  • CAS No. 1152475-42-7
  • Cat. No. CS-W000262
  • Purity ≥98%
  • MDL No. MFCD13193398
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂BrClN₂S
  • Molecular Weight 249.52
  • Synonym(s) None
  • SMILES Clc1ncc2scc(Br)c2n1

Description

7-Bromo-2-chlorothieno[3,2-d]pyrimidine features a fused thienopyrimidine core with complementary halogen substituents enabling selective cross-coupling reactions. This electron-deficient heterocycle serves as a robust scaffold for constructing bioactive molecules in medicinal chemistry and materials science.

Application

7-Bromo-2-chlorothieno[3,2-d]pyrimidine serves as a versatile building block for the synthesis of heterocyclic scaffolds in medicinal chemistry and materials science. Its dual halogenation pattern enables selective cross-coupling reactions, facilitating efficient access to functionalized thienopyrimidines. The molecule exhibits good bench stability and compatibility with standard Pd-catalyzed transformations, supporting modular derivatization for API development and advanced ligand design.

Synthesis

  • Route1
    • null|null
      1293987-55-9
    • ~85%
    • In-stock
      7-bromo-2-chlorothieno[3,2-d]pyrimidine|CS-W000262
      1152475-42-7

    References

    • KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; SIM, Tae Bo; CHOI, Hwan Geun; HAH, Jung Mi; HAM, Young Jin; JUN, Eun Jin; LEE, Jung Hun; KIM, Hwan Patent: WO2011/49332 A2, 2011 ; Location in patent: Page/Page column 17 ; WO 2011/049332 A2
  • Route2
    • In-stock
      2-Chlorothieno[3,2-d]pyrimidine|CS-W006642
      1119280-68-0
    • ~74%
    • In-stock
      7-bromo-2-chlorothieno[3,2-d]pyrimidine|CS-W000262
      1152475-42-7

    References

    • CYTOPIA RESEARCH PTY LTD Patent: WO2009/62258 A1, 2009 ; Location in patent: Page/Page column 92 ; WO 2009/062258 A1
  • Route3

    References

    • GATEKEEPER PHARMACEUTICAL, INC.; GRAY, Nathanael, S.; ZHOU, Wenjun Patent: WO2011/79231 A1, 2011 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   3.1072
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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