Lot numbers can be found on the outside label of a product:
2-Chlorothieno[3,2-d]pyrimidine
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CAS No. 1119280-68-0
- Cat. No. CS-W006642
- Purity≥97%
- MDL No.MFCD12406127
*For research and further manufacturing use only, not for direct human use.
![2-Chlorothieno[3,2-d]pyrimidine|CS-W006642](https://file.chemscene.com/productPIC/CS-W006642.gif)
Structure of 1119280-68-0
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General Information
- CAS No. 1119280-68-0
- Cat. No. CS-W006642
- Purity ≥97%
- MDL No. MFCD12406127
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₃ClN₂S
- Molecular Weight 170.62
- Synonym(s) 2-Chloro-thieno[3,2-d]pyrimidine
- SMILES ClC1=NC2=C(C=N1)SC=C2
Description
2-Chlorothieno[3,2-d]pyrimidine features a fused thienopyrimidine core with a chlorine substituent at the 2-position, delivering enhanced electron deficiency and improved metabolic stability. This scaffold integrates readily into kinase inhibitors and bioactive heterocycles, offering high reactivity in cross-coupling and nucleophilic substitution reactions under standard conditions.
Application
2-Chlorothieno[3,2-d]pyrimidine serves as a versatile heterocyclic building block for medicinal chemistry and materials science, enabling efficient construction of kinase inhibitors and functionalized π-conjugated systems. Its chlorine substituent facilitates palladium-catalyzed cross-coupling reactions, while the fused thienopyrimidine core provides enhanced metabolic stability and planar rigidity. The compound exhibits excellent bench stability and compatibility with diverse reaction conditions, making it a practical scaffold for high-throughput synthesis and API development.
Synthesis
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Route1
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In-stock
![2,4-Dichlorothieno[3,2-d]pyrimidine|CS-B0058](https://file.chemscene.com/productPIC/CS-B0058.gif)
16234-14-3 - ~99%
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In-stock
1119280-68-0
References
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GATEKEEPER PHARMACEUTICAL, INC.; GRAY, Nathanael, S.; ZHOU, Wenjun Patent: WO2011/79231 A1, 2011 ; Location in patent: Page/Page column 82 ;
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Route2
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In-stock
![Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione|CS-B0057](https://file.chemscene.com/productPIC/CS-B0057.gif)
16233-51-5 - ~%
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In-stock
1119280-68-0
References
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ACS Medicinal Chemistry Letters, , vol. 2, # 2 p. 154 - 159
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Route3
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In-stock
22288-78-4 - ~%
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In-stock
1119280-68-0
References
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WO2011/79231 A1, ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 25.78
- LogP 2.3447
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 0
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