4-Methyl-4,7-diazaspiro[2.5]octane dihydrochloride

Name: 4-Methyl-4,7-diazaspiro[2.5]octane dihydrochloride
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CAS No. 1152111-72-2
Cat. No. CS-0120195
Purity≥95%
MDL No.None

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4-Methyl-4,7-diazaspiro[2.5]octane dihydrochloride|CS-0120195

Structure of 1152111-72-2

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General Information

CAS No. 1152111-72-2
Cat. No. CS-0120195
Purity ≥95%
MDL No. None
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₆Cl₂N₂
Molecular Weight 199.12
Synonym(s) 4-methyl-4,7-diazaspiro[2.5]octane d ihydrochloride
SMILES CN(CCNC1)C21CC2.[H]Cl.[H]Cl

Description

4-Methyl-4,7-diazaspiro[2.5]octane dihydrochloride is a rigid, nitrogen-rich spirocyclic scaffold featuring a sterically constrained bicyclic core with two tertiary amine centers. This configuration enables strong protonation and enhanced solubility in aqueous and polar organic media. The compound serves as a privileged building block in medicinal chemistry for constructing bioactive heterocycles, particularly in the design of kinase inhibitors and CNS-targeted molecules. Its bench-stable nature simplifies handling in synthetic workflows.

Application

4-Methyl-4,7-diazaspiro[2.5]octane dihydrochloride serves as a rigid, bicyclic scaffold for medicinal chemistry applications, offering enhanced metabolic stability and defined stereochemistry. The spirocyclic core enables precise spatial positioning of functional groups, facilitating targeted interactions in drug discovery. Its dihydrochloride salt form ensures excellent solubility and shelf stability, while the tertiary amine centers support straightforward derivatization. This compound functions as a key building block in the synthesis of bioactive heterocycles and scaffolds relevant to CNS-targeted therapeutics.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 15.27
LogP 0.8976
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Building Blocks Skeleton Spirol Rings compounds

Key Words

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4-Methyl-4,7-diazaspiro[2.5]octane dihydrochloride

CAS No. 1152111-72-2

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