Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Methyl 1,2,3,4-tetrahydroquinoline-6-carboxylate

  • CAS No. 177478-49-8

  • Cat. No. CS-0044459
  • Purity≥97%
  • MDL No.MFCD08692534

*For research and further manufacturing use only, not for direct human use.

Methyl 1,2,3,4-tetrahydroquinoline-6-carboxylate|CS-0044459

Structure of 177478-49-8

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 177478-49-8
  • Cat. No. CS-0044459
  • Purity ≥97%
  • MDL No. MFCD08692534
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₃NO₂
  • Molecular Weight 191.23
  • Synonym(s) 6-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-, methyl ester
  • SMILES O=C(C1=CC2=C(NCCC2)C=C1)OC

Description

Methyl 1,2,3,4-tetrahydroquinoline-6-carboxylate features a saturated quinoline core with a strategically positioned ester group, enabling direct functionalization at the C6 position. This bench-stable scaffold integrates seamlessly into synthetic routes targeting bioactive heterocycles and pharmaceutical intermediates.

Application

Methyl 1,2,3,4-tetrahydroquinoline-6-carboxylate serves as a versatile building block in medicinal chemistry, enabling late-stage functionalization via the electron-rich tetrahydroquinoline core. Its methyl ester group facilitates straightforward derivatization, while the saturated heterocyclic scaffold offers enhanced metabolic stability and favorable pharmacokinetic properties. The compound exhibits good bench stability and compatibility with standard coupling reactions, making it well-suited for constructing complex alkaloid-like scaffolds and bioactive molecules in drug discovery campaigns.

Synthesis

  • Route1
    • null|null
      186581-53-3
    • In-stock
      1,2,3,4-Tetrahydroquinoline-6-carboxylic acid|CS-W006431
      5382-49-0
    • ~99%
    • In-stock
      Methyl 1,2,3,4-tetrahydroquinoline-6-carboxylate|CS-0044459
      177478-49-8

    References

    • METHYLGENE INC. Patent: WO2007/118137 A1, 2007 ; Location in patent: Page/Page column 131 ;
  • Route2
    • In-stock
      Methyl quinoline-6-carboxylate|CS-W002712
      38896-30-9
    • ~40%
    • Methyl 5,6,7,8-tetrahydroquinoline-6-carboxylate|CS-0970192
      76384-36-6
    • In-stock
      Methyl 1,2,3,4-tetrahydroquinoline-6-carboxylate|CS-0044459
      177478-49-8

    References

    • Journal of Organic Chemistry, , vol. 67, # 22 p. 7890 - 7893
  • Route3

    References

    • US6300342 B1, ; US 6300342 B1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   38.33
  • LogP   1.8313
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 177478-49-8 sigma177478-49-8 manufacturer177478-49-8 price177478-49-8 structure177478-49-8 SDSbuy 177478-49-8177478-49-8 supplier177478-49-8 uses177478-49-8 molecular weightprice of 177478-49-8177478-49-8 chemical name formula of 177478-49-8
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label