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CS-W001157 4
Total: USD 88.00

SPDB

  • CAS No. 115088-06-7

  • Cat. No. CS-5677
  • Purity≥98%
  • MDL No.MFCD20229028

*For research and further manufacturing use only, not for direct human use.

SPDB|CS-5677

Structure of 115088-06-7

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General Information

  • CAS No. 115088-06-7
  • Cat. No. CS-5677
  • Purity ≥98%
  • MDL No. MFCD20229028
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₄N₂O₄S₂
  • Molecular Weight None
  • Synonym(s) N-Succinimidyl 4-(2-pyridyldithio)butanoate
  • SMILES O=C(CC1)N(OC(CCCSSC2=NC=CC=C2)=O)C1=O

Description

SPDB is a cleavable, maleimide-functionalized crosslinker designed for site-specific conjugation of biomolecules. Featuring a stable thioether linkage and a labile disulfide bond, it enables efficient bioconjugation under physiological conditions while facilitating controlled release in reducing environments. This property makes SPDB ideal for antibody-drug conjugate development and targeted delivery systems.

Application

SPDB serves as a reliable, bench-stable sulfonamide-based crosslinker for protein conjugation and bioconjugate synthesis. Its reactive sulfonyl chloride group enables efficient coupling with primary amines under mild conditions, offering high functional group tolerance and straightforward purification. Widely used in antibody-drug conjugate (ADC) development and chemical biology applications, SPDB facilitates site-specific modification with minimal side reactions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   76.57
  • LogP   2.2093
  • H_Acceptors   7
  • H_Donors   0
  • Rotatable_Bonds   7

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