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CS-W001157 4
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5-Bromo-3-methoxypicolinic acid

  • CAS No. 1142191-66-9

  • Cat. No. CS-0108720
  • Purity≥98%
  • MDL No.MFCD11857696

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-methoxypicolinic acid|CS-0108720

Structure of 1142191-66-9

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General Information

  • CAS No. 1142191-66-9
  • Cat. No. CS-0108720
  • Purity ≥98%
  • MDL No. MFCD11857696
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrNO₃
  • Molecular Weight 232.03
  • Synonym(s) Ambroxol Impurity I
  • SMILES O=C(O)C1=NC=C(Br)C=C1OC

Description

5-Bromo-3-methoxypicolinic acid features a bromine substituent at the 5-position and a methoxy group at the 3-position of the picolinic acid scaffold, delivering enhanced electron-withdrawing character and improved solubility in organic media. This combination facilitates efficient coupling reactions in synthetic medicinal chemistry, particularly in the construction of heterocyclic scaffolds and bioactive molecules.

Application

5-Bromo-3-methoxypicolinic acid serves as a versatile building block in synthetic medicinal chemistry, enabling direct functionalization at the pyridine core. The bromo group facilitates palladium-catalyzed cross-coupling reactions, while the methoxy and carboxylic acid functionalities offer orthogonal handles for derivatization. Its bench-stable solid form and compatibility with standard reaction conditions make it well-suited for iterative synthesis of heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   1.5509
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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