Pyrazolo[1,5-a]pyridin-5-amine

Name: Pyrazolo[1,5-a]pyridin-5-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1101120-37-9
Cat. No. CS-W006749
Purity≥98%
MDL No.MFCD19215457

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Pyrazolo[1,5-a]pyridin-5-amine|CS-W006749

Structure of 1101120-37-9

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General Information

CAS No. 1101120-37-9
Cat. No. CS-W006749
Purity ≥98%
MDL No. MFCD19215457
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₇N₃
Molecular Weight 133.15
Synonym(s) H-pyrazolo[1,5-a]pyridin-5-aMine
SMILES NC1=CC2=CC=NN2C=C1

Description

Pyrazolo[1,5-a]pyridin-5-amine delivers a rigid, electron-rich heterocyclic scaffold ideal for medicinal chemistry applications. This nitrogen-dense framework integrates readily into kinase inhibitors and other bioactive molecules, offering enhanced binding affinity through π-stacking and hydrogen-bonding interactions. The pendant amine enables direct derivatization, streamlining the synthesis of targeted compounds.

Application

Pyrazolo[1,5-a]pyridin-5-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to kinase inhibitors and other bioactive scaffolds. Its electron-rich pyrazolo-pyridine core exhibits favorable reactivity in C–H functionalization and palladium-catalyzed couplings, while the primary amine facilitates downstream derivatization. The compound demonstrates good bench stability and compatibility with common protecting group strategies, supporting its use in multi-step synthesis and API development workflows.

Synthesis

Route1
- In-stock
  
  1101120-33-5
- ~57%
- In-stock
  
  1101120-37-9
References
- IRM LLC; NOVARTIS AG; CHATTERJEE, Arnab Kumar; NAGLE, Advait Suresh; PARASELLI, Prasuna; KONDREDDI, Ravinder Reddy; LEONG, Seh Yong; MISHRA, Pranab Kumar; MOREAU, Robert Joseph; ROLAND, Jason Thomas; SIM, Wei Lin Sandra; SIMON, Oliver; TAN, Liying Jocelyn; YEUNG, Bryan KS; ZOU, Bin; BOLLU, Venkatataiah Patent: WO2014/78802 A1, 2014 ; Location in patent: Page/Page column 252; 253 ;
Route2
- In-stock
  
  98400-69-2
- ~%
- In-stock
  
  1101120-37-9
References
- Kendall, Jackie D.; O'Connor, Patrick D.; Marshall, Andrew J.; Frederick, Raphael; Marshall, Elaine S.; Lill, Claire L.; Lee, Woo-Jeong; Kolekar, Sharada; Chao, Mindy; Malik, Alisha; Yu, Shuqiao; Chaussade, Claire; Buchanan, Christina; Rewcastle, Gordon W.; Baguley, Bruce C.; Flanagan, Jack U.; Jamieson, Stephen M.F.; Denny, William A.; Shepherd, Peter R. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 1 p. 69 - 85

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 43.32
LogP 0.9165
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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Pyrazolo[1,5-a]pyridin-5-amine

CAS No. 1101120-37-9

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