tert-Butyl (2-oxopyrrolidin-3-yl)carbamate

Name: tert-Butyl (2-oxopyrrolidin-3-yl)carbamate
Brand: ChemScene
Availability: InStock
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CAS No. 99780-97-9
Cat. No. CS-W006138
Purity≥95%
MDL No.MFCD11007813

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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tert-Butyl (2-oxopyrrolidin-3-yl)carbamate|CS-W006138

Structure of 99780-97-9

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General Information

CAS No. 99780-97-9
Cat. No. CS-W006138
Purity ≥95%
MDL No. MFCD11007813
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₆N₂O₃
Molecular Weight 200.23
Synonym(s) tert-butyl N-(2-oxopyrrolidin-3-yl)carbamate
SMILES CC(C)(OC(NC1CCNC1=O)=O)C

Description

tert-Butyl (2-oxopyrrolidin-3-yl)carbamate serves as a stable, moisture-tolerant protecting group for primary amines in peptide synthesis and small-molecule conjugation. The carbamate moiety integrates seamlessly into complex architectures, offering selective deprotection under mild acidic conditions. This scaffold enables efficient access to functionalized pyrrolidine derivatives with enhanced solubility and handling convenience.

Application

tert-Butyl (2-oxopyrrolidin-3-yl)carbamate serves as a stable, bench-friendly building block for the synthesis of pyrrolidine-based scaffolds. Its oxo group enables selective functionalization at C3, while the Boc-protected amine facilitates orthogonal manipulation in multi-step sequences. This compound functions effectively in standard coupling reactions and heterocycle construction, offering predictable reactivity and ease of purification in medicinal chemistry workflows.

Synthesis

Route1
- In-stock
  
  24424-99-5
- 2483-65-0
- ~99%
- In-stock
  
  99780-97-9
References
- Pajouhesh, Hassan; Pajouhesh, Hossein; Ding, Yanbing; Snutch, Terrance P. Patent: US2005/165065 A1, 2005 ; Location in patent: Page/Page column 24 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 67.43
LogP 0.3996
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Key Words

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tert-Butyl (2-oxopyrrolidin-3-yl)carbamate

CAS No. 99780-97-9

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