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CS-W001157 4
Total: USD 88.00

2-(6-Bromopyridin-2-yl)acetic acid

  • CAS No. 1093879-46-9

  • Cat. No. CS-0042093
  • Purity≥95%
  • MDL No.MFCD10000075

*For research and further manufacturing use only, not for direct human use.

2-(6-Bromopyridin-2-yl)acetic acid|CS-0042093

Structure of 1093879-46-9

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General Information

  • CAS No. 1093879-46-9
  • Cat. No. CS-0042093
  • Purity ≥95%
  • MDL No. MFCD10000075
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrNO₂
  • Molecular Weight 216.03
  • Synonym(s) None
  • SMILES O=C(O)CC1=NC(Br)=CC=C1

Description

This brominated pyridine-acetic acid derivative features a reactive carboxylic acid group flanked by a brominated heteroaryl moiety, enabling direct coupling in cross-coupling or functionalization workflows. The electron-deficient pyridine ring enhances regioselectivity in palladium-catalyzed transformations, while the bench-stable structure simplifies handling and integration into synthetic sequences.

Application

2-(6-Bromopyridin-2-yl)acetic acid serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its brominated pyridine moiety. The carboxylic acid group facilitates direct derivatization or salt formation, enhancing solubility and purification. Its bench-stable nature and compatibility with standard synthetic protocols make it ideal for constructing heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1
    • null|null
      1387560-41-9
    • ~76%
    • In-stock
      2-(6-Bromopyridin-2-yl)acetic acid|CS-0042093
      1093879-46-9

    References

    • BADIGER, Sangamesh; CHEBROLU, Murali; HURTH, Konstanze; JACQUIER, Sébastien; LUEOEND, Rainer Martin; MACHAUER, Rainer; RUEEGER, Heinrich; TINTELNOT-BLOMLEY, Marina; VEENSTRA, Siem Jacob; VOEGTLE, Markus Patent: US2012/184539 A1, 2012 ; Location in patent: Page/Page column 25 ; US 20120184539 A1
  • Route2

    References

    • US2012/184539 A1, ; US 20120184539 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.4712
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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