1,1-Dimethylethyl (4R)-4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylate

Name: 1,1-Dimethylethyl (4R)-4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 108149-63-9
Cat. No. CS-0011755
Purity≥97%
MDL No.MFCD06202686

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1,1-Dimethylethyl (4R)-4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylate|CS-0011755

Structure of 108149-63-9

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 108149-63-9
Cat. No. CS-0011755
Purity ≥97%
MDL No. MFCD06202686
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₂₁NO₄
Molecular Weight 231.29
Synonym(s) 3-Oxazolidinecarboxylic acid, 4-(hydroxymethyl)-2,2-dimethyl-, 1,1-dimethylethyl ester, (R)-; (R)-4-Hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester; tert-butyl (4R)-4-(hydroxymethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
SMILES OC[C@@H]1COC(C)(C)N1C(OC(C)(C)C)=O

Description

This oxazolidine derivative features a chiral hydroxymethyl group and a tert-butyl ester, enabling stereocontrolled synthesis in medicinal chemistry. The bench-stable, moisture-tolerant scaffold integrates readily into complex molecular architectures, offering high functional group compatibility for peptide and heterocyclic compound development.

Application

1,1-Dimethylethyl (4R)-4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylate serves as a robust chiral synthon for the construction of oxazolidine-based scaffolds. The protected hydroxymethyl group enables selective derivatization, while the oxazolidine core provides excellent functional group tolerance and bench stability. This compound facilitates stereoselective transformations in peptide-like sequence synthesis and offers straightforward deprotection under mild acidic conditions, making it well-suited for iterative synthetic workflows.

Synthesis

Route1
- In-stock
  
  95715-86-9
- ~10%
- In-stock
  
  108149-63-9
References
- CHUGAI SEIYAKU KABUSHIKI KAISHA Patent: WO2005/87700 A2, 2005 ; Location in patent: Page/Page column 322 ; WO 2005/087700 A2
Route2
- In-stock
  
  102308-32-7
- ~73%
- In-stock
  
  108149-63-9
References
- Garner, Philip; Park, Jung Min Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2361 - 2364
Route3
- In-stock
  
  2766-43-0
- ~%
- In-stock
  
  108149-63-9
References
- Journal of Organic Chemistry, , vol. 72, # 4 p. 1218 - 1225

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 59
LogP 1.3507
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Oxazolidine compounds

Key Words

108149-63-9 sigma108149-63-9 manufacturer108149-63-9 price108149-63-9 structure108149-63-9 SDSbuy 108149-63-9108149-63-9 supplier108149-63-9 uses108149-63-9 molecular weightprice of 108149-63-9108149-63-9 chemical name formula of 108149-63-9

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

1,1-Dimethylethyl (4R)-4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylate

CAS No. 108149-63-9

Recommended Products

General Information

Description

Application

Synthesis

References

References

References

Safety Information

Quality Control

Computational Chemistry Data

Similar Products

Other Classifications

Recently Viewed Products

Key Words