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CS-W001157 4
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2-(4-Methoxy-2-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 1073353-81-7

  • Cat. No. CS-0176624
  • Molecule weightNone
  • Purity≥95%
  • MDL No.MFCD10699701

*For research and further manufacturing use only, not for direct human use.

2-(4-Methoxy-2-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0176624

Structure of 1073353-81-7

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General Information

  • CAS No. 1073353-81-7
  • Cat. No. CS-0176624
  • Purity ≥95%
  • MDL No. MFCD10699701
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₈BNO₅
  • Molecular Weight None
  • Synonym(s) None
  • SMILES CC1(C)C(C)(C)OB(C2=CC=C(OC)C=C2[N+]([O-])=O)O1

Description

This boronate reagent features a methoxy-substituted nitroaryl group, enabling efficient coupling in Suzuki-Miyaura reactions. The tetramethyl-substituted dioxaborolane ring provides enhanced stability and moisture tolerance, simplifying handling under standard conditions.

Application

2-(4-Methoxy-2-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. The 4-methoxy-2-nitrophenyl moiety enables efficient functionalization of heterocyclic and aromatic scaffolds, with the tetramethyl dioxaborolane group offering excellent stability, predictable reactivity, and compatibility with diverse reaction conditions. Ideal for iterative synthesis in medicinal chemistry and materials science workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   70.83
  • LogP   1.9026
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   3

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