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CS-W001157 4
Total: USD 88.00

2,4-Dibromo-3-chloropyridine

  • CAS No. 861024-77-3

  • Cat. No. CS-0106375
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,4-Dibromo-3-chloropyridine|CS-0106375

Structure of 861024-77-3

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General Information

  • CAS No. 861024-77-3
  • Cat. No. CS-0106375
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂Br₂ClN
  • Molecular Weight 271.34
  • Synonym(s) 2,4-Diboromo-3-chloropyridine
  • SMILES ClC1=C(Br)C=CN=C1Br

Description

2,4-Dibromo-3-chloropyridine features a halogenated pyridine core with complementary reactivity at multiple positions. This electron-deficient heterocycle integrates readily into cross-coupling protocols and serves as a robust scaffold for constructing functionalized aromatic systems under standard conditions.

Application

2,4-Dibromo-3-chloropyridine serves as a versatile building block in heterocyclic synthesis, enabling regioselective cross-coupling reactions due to its complementary halogen reactivity profile. The bromine and chlorine substituents facilitate sequential Pd-catalyzed coupling processes, allowing efficient construction of complex pyridine-based scaffolds. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • 3-Chloropyridine-2,4-diol|CS-0307974
      103792-81-0
    • ~%
    • In-stock
      2,4-Dibromo-3-chloropyridine|CS-0106375
      861024-77-3

    References

    • den Hertog Recueil des Travaux Chimiques des Pays-Bas, 1945 , vol. 64, p. 85,98 Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 673,681

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.26
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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