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CS-W001157 4
Total: USD 88.00

2-Bromo-3-chloropyridine

  • CAS No. 96424-68-9

  • Cat. No. CS-W007662
  • Purity≥98%
  • MDL No.MFCD04039344

*For research and further manufacturing use only, not for direct human use.

2-Bromo-3-chloropyridine|CS-W007662

Structure of 96424-68-9

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General Information

  • CAS No. 96424-68-9
  • Cat. No. CS-W007662
  • Purity ≥98%
  • MDL No. MFCD04039344
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrClN
  • Molecular Weight None
  • Synonym(s) None
  • SMILES BrC1=C(Cl)C=CC=N1

Description

2-Bromo-3-chloropyridine features a halogenated pyridine core with complementary reactivity at adjacent positions, enabling selective cross-coupling and functionalization in synthetic pathways. This bench-stable heterocycle integrates readily into pharmaceutical intermediates and agrochemical scaffolds under standard conditions.

Application

2-Bromo-3-chloropyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling selective cross-coupling reactions via its halogenated positions. The ortho-bromo and meta-chloro substituents provide complementary reactivity for palladium-catalyzed coupling protocols, allowing efficient construction of complex heterocyclic scaffolds. Its bench-stable nature and compatibility with standard purification methods make it well-suited for iterative synthetic workflows.

Synthesis

  • Route1

    References

    • Choppin, Sabine; Gros, Philippe; Fort, Yves European Journal of Organic Chemistry, 2001 , # 3 p. 603 - 606
  • Route2

    References

    • Schlosser, Manfred; Cottet, Fabrice European Journal of Organic Chemistry, 2002 , # 24 p. 4181 - 4184
  • Route3
    • In-stock
      3-Chloropyridine|CS-W011253
      626-60-8
    • ~82%
    • null|null
      98273-80-4
    • In-stock
      2-Bromo-3-chloropyridine|CS-W007662
      96424-68-9

    References

    • Hebel, David; Rozen, Shlomo Journal of Organic Chemistry, 1988 , vol. 53, # 5 p. 1123 - 1125

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.4975
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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