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Methyl 6-(aminomethyl)pyridine-3-carboxylate hydrochloride

  • CAS No. 1072438-56-2

  • Cat. No. CS-0048958
  • Molecule weight202.64
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 6-(aminomethyl)pyridine-3-carboxylate hydrochloride|CS-0048958

Structure of 1072438-56-2

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General Information

  • CAS No. 1072438-56-2
  • Cat. No. CS-0048958
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁ClN₂O₂
  • Molecular Weight 202.64
  • Synonym(s) Methyl 6-(aminomethyl)nicotinate hydrochloride
  • SMILES Cl.COC(=O)C1=CN=C(CN)C=C1

Description

Methyl 6-(aminomethyl)pyridine-3-carboxylate hydrochloride offers a pyridyl scaffold with dual functional handles: a basic amine for conjugation and a methyl ester for derivatization. This bench-stable salt delivers enhanced solubility in aqueous media, enabling efficient incorporation into bioconjugation workflows and medicinal chemistry campaigns.

Application

Methyl 6-(aminomethyl)pyridine-3-carboxylate hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds. The ortho-aminoalkyl functionality facilitates direct derivatization via alkylation or reductive amination, while the methyl ester supports standard transformations such as hydrolysis or coupling reactions. Bench-stable and readily purified by recrystallization, it functions effectively in multi-step syntheses requiring functional group compatibility and predictable reactivity.

Synthesis

  • Route1
    • null|null
      1126794-84-0
    • ~34%
    • In-stock
      Methyl 6-(aminomethyl)pyridine-3-carboxylate hydrochloride|CS-0048958
      1072438-56-2

    References

    • PURDUE PHARMA L.P.; SHIONOGI and CO., LTD. Patent: WO2009/27820 A2, 2009 ; Location in patent: Page/Page column 257 ; WO 2009/027820 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   65.21
  • LogP   0.7487
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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