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1-Methylpyrrolidin-3-amine dihydrochloride

  • CAS No. 1209287-84-2

  • Cat. No. CS-0151106
  • Purity≥95%
  • MDL No.MFCD13195986

*For research and further manufacturing use only, not for direct human use.

1-Methylpyrrolidin-3-amine dihydrochloride|CS-0151106

Structure of 1209287-84-2

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General Information

  • CAS No. 1209287-84-2
  • Cat. No. CS-0151106
  • Purity ≥95%
  • MDL No. MFCD13195986
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₄Cl₂N₂
  • Molecular Weight 173.08
  • Synonym(s) 1-Methyl-3-pyrrolidinaMine 2HCl
  • SMILES CN1CCC(C1)N.Cl.Cl

Description

1-Methylpyrrolidin-3-amine dihydrochloride is a bench-stable, moisture-tolerant amine offering enhanced solubility in aqueous and protic solvents. This nitrogen-rich scaffold integrates readily into medicinal chemistry libraries, serving as a key building block for bioactive molecules. The protonated form ensures high reactivity in nucleophilic substitution and coupling reactions under standard conditions.

Application

1-Methylpyrrolidin-3-amine dihydrochloride serves as a versatile nitrogen-containing building block in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its tertiary amine functionality offers enhanced solubility and metabolic stability, while the pyrrolidine core provides structural rigidity for target engagement. The dihydrochloride salt enhances bench stability and simplifies purification, facilitating its use in standard coupling reactions, reductive aminations, and scaffold diversification workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   0.4928
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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