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(S)-5-(Aminomethyl)pyrrolidin-2-one hydrochloride

  • CAS No. 2248666-06-8

  • Cat. No. CS-0144990
  • Purity≥70%
  • MDL No.MFCD26954831

*For research and further manufacturing use only, not for direct human use.

(S)-5-(Aminomethyl)pyrrolidin-2-one hydrochloride|CS-0144990

Structure of 2248666-06-8

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General Information

  • CAS No. 2248666-06-8
  • Cat. No. CS-0144990
  • Purity ≥70%
  • MDL No. MFCD26954831
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁ClN₂O
  • Molecular Weight 150.61
  • Synonym(s) (S)-5-Aminomethyl-pyrrolidin-2-one hydrochloride
  • SMILES O=C1N[C@H](CN)CC1.[H]Cl

Description

(S)-5-(Aminomethyl)pyrrolidin-2-one hydrochloride is a chiral pyrrolidinone derivative featuring a primary amine at the 5-position, enabling direct conjugation or functionalization in synthetic workflows. This bench-stable salt form enhances solubility and handling, facilitating integration into peptide mimetics, kinase inhibitors, and bioactive scaffolds requiring precise stereochemistry.

Application

(S)-5-(Aminomethyl)pyrrolidin-2-one hydrochloride serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its pyrrolidinone core offers favorable solubility and stability, while the pendant primary amine facilitates straightforward derivatization via amidation, alkylation, or reductive amination. The compound functions reliably in standard coupling protocols and is well-suited for parallel synthesis campaigns requiring stereocontrolled scaffold elaboration.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   -0.3545
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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