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CS-W001157 4
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(S)-1-(6-(trifluoromethyl)pyridin-3-yl)ethan-1-amine

  • CAS No. 1071435-62-5

  • Cat. No. CS-0492379
  • Purity≥97%
  • MDL No.MFCD09256747

*For research and further manufacturing use only, not for direct human use.

(S)-1-(6-(trifluoromethyl)pyridin-3-yl)ethan-1-amine|CS-0492379

Structure of 1071435-62-5

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General Information

  • CAS No. 1071435-62-5
  • Cat. No. CS-0492379
  • Purity ≥97%
  • MDL No. MFCD09256747
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉F₃N₂
  • Molecular Weight 190.17
  • Synonym(s) (S)-1-(6-(Trifluoromethyl)pyridin-3-YL)ethanamine
  • SMILES C[C@H](N)C1C=NC(=CC=1)C(F)(F)F

Description

(S)-1-(6-(trifluoromethyl)pyridin-3-yl)ethan-1-amine features a chiral ethylamine side chain attached to a trifluoromethyl-substituted pyridine ring, delivering enhanced electronic and steric properties. This configuration enables precise molecular recognition in asymmetric synthesis, serving as a key scaffold for bioactive molecule construction. The compound exhibits robust bench stability and compatibility with diverse reaction conditions.

Application

(S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethan-1-amine serves as a versatile chiral building block for medicinal chemistry, enabling the construction of pyridine-containing scaffolds prevalent in pharmaceuticals. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the chiral amine functionality facilitates stereoselective transformations. The compound exhibits good bench stability and compatibility with standard coupling reactions, simplifying purification and integration into multi-step syntheses.

Synthesis

  • Route1
    • null|null
      1071435-65-8
    • ~97%
    • In-stock
      (S)-1-(6-(trifluoromethyl)pyridin-3-yl)ethan-1-amine|CS-0492379
      1071435-62-5

    References

    • RENOVIS, INC. Patent: WO2008/123963 A1, 2008 ; Location in patent: Page/Page column 50 ; WO 2008/123963 A1
  • Route2
    • null|null
      358780-13-9
    • ~%
    • In-stock
      (S)-1-(6-(trifluoromethyl)pyridin-3-yl)ethan-1-amine|CS-0492379
      1071435-62-5

    References

    • RENOVIS, INC. Patent: WO2008/123963 A1, 2008 ; WO 2008/123963 A1
  • Route3

    References

    • RENOVIS, INC. Patent: WO2008/123963 A1, 2008 ; WO 2008/123963 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.1201
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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