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CS-W001157 4
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6,7-Dihydro-5H-cyclopenta[b]pyridin-5-ol

  • CAS No. 1065609-70-2

  • Cat. No. CS-0060663
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6,7-Dihydro-5H-cyclopenta[b]pyridin-5-ol|CS-0060663

Structure of 1065609-70-2

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General Information

  • CAS No. 1065609-70-2
  • Cat. No. CS-0060663
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO
  • Molecular Weight 135.16
  • Synonym(s) 5H,6H,7H-cyclopenta[b]pyridin-5-ol
  • SMILES C1=CC2=C(CCC2O)N=C1

Description

6,7-Dihydro-5H-cyclopenta[b]pyridin-5-ol features a fused bicyclic core with a phenolic hydroxyl group, offering enhanced solubility and stability in polar solvents. This scaffold integrates readily into synthetic routes for bioactive heterocycles, serving as a key intermediate in medicinal chemistry campaigns targeting CNS modulators and kinase inhibitors.

Application

6,7-Dihydro-5H-cyclopenta[b]pyridin-5-ol serves as a valuable heterocyclic building block in medicinal chemistry, offering a rigid, bicyclic scaffold with a polar hydroxyl group at the 5-position. The compound exhibits good bench stability and facilitates downstream functionalization via electrophilic substitution or coupling reactions. Its structural motif is relevant to bioactive molecule design, particularly in CNS-targeted therapeutics, where its fused ring system contributes to conformational constraint and improved metabolic stability.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.0612
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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