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CS-W001157 4
Total: USD 88.00

Benzo[d]thiazol-2-ylmethanol

  • CAS No. 37859-42-0

  • Cat. No. CS-W017888
  • Purity≥98%
  • MDL No.MFCD00226293

*For research and further manufacturing use only, not for direct human use.

Benzo[d]thiazol-2-ylmethanol|CS-W017888

Structure of 37859-42-0

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General Information

  • CAS No. 37859-42-0
  • Cat. No. CS-W017888
  • Purity ≥98%
  • MDL No. MFCD00226293
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇NOS
  • Molecular Weight 165.21
  • Synonym(s) 1,3-Benzothiazol-2-ylmethanol
  • SMILES OCC1=NC2=CC=CC=C2S1

Description

Benzo[d]thiazol-2-ylmethanol features a benzothiazole scaffold with a reactive primary alcohol handle, enabling direct functionalization in synthetic transformations. This bench-stable, moisture-tolerant heterocycle integrates readily into bioactive molecule design and serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and fluorescent probes.

Application

Benzo[d]thiazol-2-ylmethanol serves as a versatile building block in medicinal chemistry, enabling efficient synthesis of bioactive heterocycles. Its benzothiazole core imparts metabolic stability and favorable pharmacokinetic properties, while the pendant alcohol group facilitates derivatization via oxidation, protection, or coupling reactions. The compound exhibits good bench stability and is compatible with standard reaction conditions, making it well-suited for iterative synthetic workflows in API development.

Synthesis

  • Route1
    • Benzothiazole, ≥96%|CS-1269066
      95-16-9
    • null|null
      67-56-1
    • ~70%
    • In-stock
      Benzo[d]thiazol-2-ylmethanol|CS-W017888
      37859-42-0

    References

    • He, Tao; Yu, Lin; Zhang, Lei; Wang, Lei; Wang, Min Organic Letters, 2011 , vol. 13, # 19 p. 5016 - 5019
  • Route2
    • Benzothiazole, ≥96%|CS-1269066
      95-16-9
    • null|null
      50-00-0
    • ~55%
    • In-stock
      Benzo[d]thiazol-2-ylmethanol|CS-W017888
      37859-42-0

    References

    • Asselin, Sylvie M.; Bio, Matthew M.; Langille, Neil F.; Ngai, Ka Yi Organic Process Research and Development, 2010 , vol. 14, # 6 p. 1427 - 1431
  • Route3
    • In-stock
      Glycolic acid|CS-W016683
      79-14-1
    • null|null
      137-07-5
    • ~%
    • In-stock
      Benzo[d]thiazol-2-ylmethanol|CS-W017888
      37859-42-0

    References

    • Campaigne et al. Journal of Medicinal and Pharmaceutical Chemistry, 1959 , vol. 1, p. 577,594 Full Text Show Details Subarowskii Zhurnal Obshchei Khimii, 1951 , vol. 21, p. 2055,2056, 2061; engl. Ausg. S. 2295, 2301

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.7886
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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