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CS-W001157 4
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(3-Chloro-6-methoxypyridin-2-yl)methanamine

  • CAS No. 1060810-37-8

  • Cat. No. CS-0186063
  • Molecule weight172.61
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3-Chloro-6-methoxypyridin-2-yl)methanamine|CS-0186063

Structure of 1060810-37-8

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General Information

  • CAS No. 1060810-37-8
  • Cat. No. CS-0186063
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉ClN₂O
  • Molecular Weight 172.61
  • Synonym(s) None
  • SMILES COC1=CC=C(C(=N1)CN)Cl

Description

This pyridylmethanamine features a chlorinated, methoxy-substituted pyridine core that enables selective coupling in late-stage functionalization. The primary amine group facilitates conjugation with electrophiles or polymer backbones, while the electron-withdrawing chlorine enhances reactivity in nucleophilic substitution cascades. This bench-stable derivative offers high solubility in common organic solvents and tolerates moisture during standard handling protocols.

Application

(3-Chloro-6-methoxypyridin-2-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling the construction of pyridine-based scaffolds through standard coupling reactions. Its chloro and methoxy groups offer orthogonal reactivity for further functionalization, while the primary amine facilitates conjugation via amide bond formation or reductive amination. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.2023
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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