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CS-W001157 4
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N-Methyl-1-(thiophen-2-yl)methanamine

  • CAS No. 58255-18-8

  • Cat. No. CS-W018825
  • Purity≥96%
  • MDL No.MFCD04625435

*For research and further manufacturing use only, not for direct human use.

N-Methyl-1-(thiophen-2-yl)methanamine|CS-W018825

Structure of 58255-18-8

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General Information

  • CAS No. 58255-18-8
  • Cat. No. CS-W018825
  • Purity ≥96%
  • MDL No. MFCD04625435
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉NS
  • Molecular Weight 127.21
  • Synonym(s) N-methyl-2-Thiophenemethanamine
  • SMILES CNCC1=CC=CS1

Description

N-Methyl-1-(thiophen-2-yl)methanamine features a thiophene ring directly linked to a methanamine scaffold with N-methyl substitution, delivering enhanced electron density at the nitrogen center. This configuration supports efficient coupling in cross-coupling reactions and provides improved solubility in polar organic solvents. The compound serves as a key building block for heterocyclic pharmaceutical intermediates.

Application

N-Methyl-1-(thiophen-2-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling efficient access to biologically relevant heterocyclic scaffolds. Its thiophene moiety imparts favorable electronic and steric properties, while the N-methylated amine facilitates downstream functionalization via alkylation or amidation. The compound exhibits good bench stability and compatibility with standard reaction conditions, simplifying purification and integration into multi-step syntheses.

Synthesis

  • Route1
    • In-stock
      2-Thiophenecarboxaldehyde|CS-W013657
      98-03-3
    • null|null
      74-89-5
    • ~76%
    • In-stock
      N-Methyl-1-(thiophen-2-yl)methanamine|CS-W018825
      58255-18-8

    References

    • Pyun, Sang Yong; Lee, Dong Choon; Seung, Yoon Je; Cho, Bong Rae Journal of Organic Chemistry, 2005 , vol. 70, # 13 p. 5327 - 5330
  • Route2
    • null|null
      765-50-4
    • null|null
      74-89-5
    • ~%
    • In-stock
      N-Methyl-1-(thiophen-2-yl)methanamine|CS-W018825
      58255-18-8

    References

    • European Journal of Medicinal Chemistry, , vol. 64, p. 16 - 22
  • Route3
    • null|null
      54433-71-5
    • ~%
    • In-stock
      N-Methyl-1-(thiophen-2-yl)methanamine|CS-W018825
      58255-18-8

    References

    • Tetrahedron, , vol. 60, # 3 p. 569 - 575

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.4675
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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