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CS-W001157 4
Total: USD 88.00

4-Bromo-6-chloropicolinic acid

  • CAS No. 1060805-66-4

  • Cat. No. CS-0146050
  • Purity≥97%
  • MDL No.MFCD13189210

*For research and further manufacturing use only, not for direct human use.

4-Bromo-6-chloropicolinic acid|CS-0146050

Structure of 1060805-66-4

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General Information

  • CAS No. 1060805-66-4
  • Cat. No. CS-0146050
  • Purity ≥97%
  • MDL No. MFCD13189210
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClNO₂
  • Molecular Weight 236.45
  • Synonym(s) 4-bromo-6-chloropyridine-2-carboxylicaci
  • SMILES O=C(C1=NC(Cl)=CC(Br)=C1)O

Description

4-Bromo-6-chloropicolinic acid is a halogenated picolinic acid derivative featuring bromine at the 4-position and chlorine at the 6-position of the pyridine ring. This electron-deficient heterocycle integrates readily into cross-coupling reactions, serving as a robust building block for pharmaceutical intermediates and functional materials. The dual halogenation enhances reactivity in palladium-catalyzed transformations while maintaining stability under standard handling conditions.

Application

4-Bromo-6-chloropicolinic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted pyridine scaffolds. Its ortho-halogenated structure facilitates palladium-catalyzed cross-coupling reactions, while the carboxylic acid group supports direct derivatization or activation for amide bond formation. The molecule exhibits excellent bench stability and compatibility with standard purification techniques, making it well-suited for iterative synthetic campaigns and scale-up applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.1957
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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