2-Chloro-5-iodopyrazine

Name: 2-Chloro-5-iodopyrazine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1057216-55-3
Cat. No. CS-0018826
Purity≥97%
MDL No.MFCD09909701

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 1057216-55-3

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Description

2-Chloro-5-iodopyrazine is a halogenated pyrazine derivative featuring complementary reactive sites for cross-coupling. The chlorine and iodine substituents enable sequential functionalization under palladium-catalyzed conditions, facilitating rapid diversification in heterocyclic synthesis. This electron-deficient scaffold integrates efficiently into complex molecular architectures with high chemoselectivity.

Application

2-Chloro-5-iodopyrazine serves as a versatile heterocyclic building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and functionalized pyrazine scaffolds. The ortho-chloro and iodo substituents offer complementary reactivity profiles, allowing sequential functionalization with high chemoselectivity. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for iterative synthesis in medicinal chemistry and materials development.

General Information

CAS No. 1057216-55-3
Cat. No. CS-0018826
Purity ≥97%
MDL No. MFCD09909701
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₂ClIN₂
Molecular Weight 240.43
Synonym(s) 2-Chloro-5-iodo-pyrazine
SMILES IC1=CN=C(Cl)C=N1

Computational Chemistry Data

TPSA 25.78
LogP 1.7346
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

Key Words

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2-Chloro-5-iodopyrazine

CAS No. 1057216-55-3

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