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CS-W001157 4
Total: USD 88.00

3,5-Dichloro-2-iodopyrazine

  • CAS No. 136866-30-3

  • Cat. No. CS-W008615
  • Molecule weight274.87
  • Purity≥98%
  • MDL No.MFCD13189860

*For research and further manufacturing use only, not for direct human use.

3,5-Dichloro-2-iodopyrazine|CS-W008615

Structure of 136866-30-3

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General Information

  • CAS No. 136866-30-3
  • Cat. No. CS-W008615
  • Purity ≥98%
  • MDL No. MFCD13189860
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄HCl₂IN₂
  • Molecular Weight 274.87
  • Synonym(s) None
  • SMILES IC1=NC=C(Cl)N=C1Cl

Description

3,5-Dichloro-2-iodopyrazine is a halogenated pyrazine derivative featuring complementary reactivity at the 2- and 3,5-positions. This electron-deficient heterocycle serves as a key scaffold for cross-coupling transformations, enabling efficient construction of complex molecular architectures in medicinal chemistry and materials science.

Application

3,5-Dichloro-2-iodopyrazine serves as a versatile building block for the construction of substituted pyrazine scaffolds in medicinal chemistry and agrochemical research. The molecule enables palladium-catalyzed cross-coupling reactions due to its reactive iodide group, while the electron-deficient pyrazine core supports nucleophilic aromatic substitution. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for iterative synthesis workflows requiring functional group tolerance and predictable reactivity.

Synthesis

  • Route1

    References

    • Knochel, Paul; Mosrin, Marc Patent: US2011/288296 A1, 2011 ; Location in patent: Page/Page column 11 ;
  • Route2
    • In-stock
      2,6-Dichloropyrazine|CS-W010976
      4774-14-5
    • ~%
    • In-stock
      3,5-Dichloro-2-iodopyrazine|CS-W008615
      136866-30-3
    • null|null
      136866-29-0

    References

    • Turck, A.; Trohay, D.; Mojovic, L.; Ple, N.; Queguiner, G Journal of Organometallic Chemistry, 1991 , vol. 412, # 3 p. 301 - 310

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.388
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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