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CS-W001157 4
Total: USD 88.00

(2-(Trifluoromethyl)pyridin-3-yl)methanamine

  • CAS No. 1056162-06-1

  • Cat. No. CS-W005823
  • Purity≥96%
  • MDL No.MFCD10698574

*For research and further manufacturing use only, not for direct human use.

(2-(Trifluoromethyl)pyridin-3-yl)methanamine|CS-W005823

Structure of 1056162-06-1

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General Information

  • CAS No. 1056162-06-1
  • Cat. No. CS-W005823
  • Purity ≥96%
  • MDL No. MFCD10698574
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇F₃N₂
  • Molecular Weight 176.14
  • Synonym(s) 3-(Aminomethyl)-2-(trifluoromethyl)pyridine
  • SMILES NCC1=CC=CN=C1C(F)(F)F

Description

This trifluoromethylpyridylmethanamine features a pyridine ring bearing a trifluoromethyl group and a primary amine at the adjacent position, enabling direct integration into pharmaceutical scaffolds. The electron-deficient aromatic system enhances reactivity in cross-coupling and functionalization processes.

Application

(2-(Trifluoromethyl)pyridin-3-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through nucleophilic substitution and coupling reactions. Its trifluoromethylpyridine core provides enhanced metabolic stability and modulated lipophilicity, while the primary amine functionality facilitates straightforward derivatization. The compound exhibits good bench stability and is compatible with standard synthetic workflows, making it a practical choice for API intermediate development and structure–activity studies.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H314
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.5591
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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