Fmoc-α-Me-Gly(Pentynyl)-OH

Name: Fmoc-α-Me-Gly(Pentynyl)-OH
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CAS No. 1050501-65-9
Cat. No. CS-0439167
Molecule weight377.43
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 1050501-65-9
Cat. No. CS-0439167
Purity ≥98%
MDL No. None
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₃H₂₃NO₄
Molecular Weight 377.43
Synonym(s) N-α-(9-Fluorenylmethoxycarbonyl)-α-methyl-L-α-(4-pentynyl)glycine
SMILES C(OC(N[C@@](CCCC#C)(C(O)=O)C)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2

Description

Fmoc-α-Me-Gly(Pentynyl)-OH features a trifunctional scaffold integrating an Fmoc protecting group, a methylated glycine backbone, and a terminal alkyne for bioorthogonal conjugation. This derivative enables efficient copper-free click chemistry in peptide synthesis and protein labeling workflows. The pentynyl moiety facilitates site-specific coupling under mild conditions.

Application

Fmoc-α-Me-Gly(Pentynyl)-OH serves as a versatile building block for solid-phase peptide synthesis, enabling site-specific incorporation of α-methyl glycine derivatives with a terminal alkyne handle. The pentynyl side chain facilitates bioorthogonal conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the Fmoc group ensures efficient N-terminal protection and orthogonal deprotection. Its bench-stable nature and compatibility with standard coupling protocols make it ideal for synthesizing modified peptides and protein conjugates.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 75.63
LogP 4.1719
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 7

Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Valine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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Fmoc-α-Me-Gly(Pentynyl)-OH

CAS No. 1050501-65-9

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