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Structure of 1048692-61-0
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This chiral thiourea features a sterically hindered dimethylamino-substituted alkyl group paired with a strongly electron-deficient aryl scaffold, enabling precise hydrogen-bonding recognition in asymmetric catalysis. The trifluoromethylated phenyl moiety enhances lipophilicity and stability, while the (R)-configuration ensures high enantioselectivity in transition-metal-free transformations.
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]-3-[1-(dimethylamino)-3-methylbutan-2-yl]thiourea serves as a versatile chiral building block for medicinal chemistry applications, leveraging the electron-withdrawing influence of the bis(trifluoromethyl)phenyl group to modulate reactivity and metabolic stability. The thiourea moiety enables hydrogen bonding interactions in target binding, while the sterically hindered (dimethylamino)-3-methylbutan-2-yl side chain enhances conformational rigidity and solubility. This compound exhibits excellent bench stability and facilitates efficient purification, making it well-suited for high-throughput synthesis of bioactive small molecules and targeted screening libraries.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: