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CS-W001157 4
Total: USD 88.00

4,6-Dichloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine

  • CAS No. 1037479-62-1

  • Cat. No. CS-0110839
  • Purity≥98%
  • MDL No.MFCD26394969
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4,6-Dichloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine|CS-0110839

Structure of 1037479-62-1

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Description

4,6-Dichloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine features a rigid heterocyclic core with two chlorine substituents enabling selective coupling reactions. The tetrahydropyran-2-yl protecting group confers enhanced stability and solubility in organic media. This compound serves as a key intermediate for synthesizing advanced kinase inhibitors and nucleoside analogs under standard conditions.

Application

4,6-Dichloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine serves as a versatile building block for the synthesis of pyrazolopyrimidine-based scaffolds. The dichloro substitution enables sequential cross-coupling reactions, while the tetrahydropyranyl group provides orthogonal protection and enhanced solubility. This compound exhibits bench stability and facilitates efficient purification, making it well-suited for medicinal chemistry campaigns and API intermediate development.

General Information

  • CAS No. 1037479-62-1
  • Cat. No. CS-0110839
  • Purity ≥98%
  • MDL No. MFCD26394969
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀Cl₂N₄O
  • Molecular Weight 273.12
  • Synonym(s) None
  • SMILES ClC1=NC(Cl)=C2C(N(C3CCCCO3)N=C2)=N1

Computational Chemistry Data

  • TPSA   52.83
  • LogP   2.8322
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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