2-(Trifluoromethyl)pyridine-4-boronic acid, pinacol ester

Name: 2-(Trifluoromethyl)pyridine-4-boronic acid, pinacol ester
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1036990-42-7
Cat. No. CS-W000625
Purity≥97%
MDL No.MFCD09607678

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-(Trifluoromethyl)pyridine-4-boronic acid, pinacol ester|CS-W000625

Structure of 1036990-42-7

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 1036990-42-7
Cat. No. CS-W000625
Purity ≥97%
MDL No. MFCD09607678
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₅BF₃NO₂
Molecular Weight 273.06
Synonym(s) 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine
SMILES CC1(C)OB(OC1(C)C)c1ccnc(c1)C(F)(F)F

Description

2-(Trifluoromethyl)pyridine-4-boronic acid pinacol ester features a trifluoromethyl group at the ortho position, enhancing electronic withdrawal and metabolic stability. The pinacol boronate moiety enables reliable Suzuki-Miyaura coupling under standard conditions, offering robustness in cross-coupling reactions with aryl halides. This bench-stable reagent integrates efficiently into complex molecular architectures requiring electron-deficient pyridine motifs.

Application

2-(Trifluoromethyl)pyridine-4-boronic acid pinacol ester serves as a stable, bench-ready building block for Suzuki-Miyaura cross-coupling reactions. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the pyridine core provides a versatile heterocyclic scaffold. Its boronic ester functionality enables reliable coupling with aryl and heteroaryl halides under mild conditions, offering high functional group tolerance and ease of purification—ideal for medicinal chemistry and process development workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 31.35
LogP 2.3996
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Boronic Acid And Its Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

1036990-42-7 sigma1036990-42-7 manufacturer1036990-42-7 price1036990-42-7 structure1036990-42-7 SDSbuy 1036990-42-71036990-42-7 supplier1036990-42-7 uses1036990-42-7 molecular weightprice of 1036990-42-71036990-42-7 chemical name formula of 1036990-42-7

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

2-(Trifluoromethyl)pyridine-4-boronic acid, pinacol ester

CAS No. 1036990-42-7

Recommended Products