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CS-W001157 4
Total: USD 88.00

4-Bromo-3,6-dichloropyridazine

  • CAS No. 10344-42-0

  • Cat. No. CS-W018608
  • Molecule weight227.87
  • Purity≥97%
  • MDL No.MFCD13193322

*For research and further manufacturing use only, not for direct human use.

4-Bromo-3,6-dichloropyridazine|CS-W018608

Structure of 10344-42-0

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General Information

  • CAS No. 10344-42-0
  • Cat. No. CS-W018608
  • Purity ≥97%
  • MDL No. MFCD13193322
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄HBrCl₂N₂
  • Molecular Weight 227.87
  • Synonym(s) 4-Bromo-3,6-dichloropyridazine fandachem
  • SMILES ClC1=NN=C(Cl)C(Br)=C1

Description

4-Bromo-3,6-dichloropyridazine is a halogenated pyridazine derivative featuring complementary reactive sites for cross-coupling and functionalization. This electron-deficient heterocycle integrates readily into pharmaceutical intermediates and agrochemical scaffolds under standard conditions.

Application

4-Bromo-3,6-dichloropyridazine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient late-stage functionalization via Pd-catalyzed cross-coupling reactions. Its orthogonal halogen reactivity allows selective transformation of the bromo group while preserving the chloro substituents, facilitating modular scaffold diversification. The compound exhibits excellent bench stability and compatibility with standard reaction conditions, simplifying purification and scale-up in multi-step syntheses.

Synthesis

  • Route1

    References

    • Merck Sharp and Dohme Limited Patent: US6255305 B1, 2001 ; US 6255305 B1
  • Route2

    References

    • WO2007/115947 A1, ; Page/Page column 30 ;
  • Route3

    References

    • WO2008/9700 A1, ; Page/Page column 38-39 ; WO 2008/009700 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.5459
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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