4-Chloro-5-methylpyridin-2-amine

Name: 4-Chloro-5-methylpyridin-2-amine
Brand: ChemScene
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CAS No. 1033203-31-4
Cat. No. CS-0142554
Purity≥98%
MDL No.MFCD11100639

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Chloro-5-methylpyridin-2-amine|CS-0142554

Structure of 1033203-31-4

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General Information

CAS No. 1033203-31-4
Cat. No. CS-0142554
Purity ≥98%
MDL No. MFCD11100639
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂
Molecular Weight 142.59
Synonym(s) 2-Amino-4-chloro-5-methylpyridine
SMILES NC1=NC=C(C)C(Cl)=C1

Description

4-Chloro-5-methylpyridin-2-amine features a pyridine core functionalized with chlorine and methyl groups at the 4- and 5-positions, respectively, enabling tailored reactivity in cross-coupling and medicinal chemistry applications. The ortho-chloro substituent enhances electrophilic engagement, while the para-methyl group provides steric and electronic modulation. This scaffold serves as a key building block for kinase inhibitors and agrochemicals, offering robust stability under standard conditions.

Application

4-Chloro-5-methylpyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based heterocycles via palladium-catalyzed cross-coupling reactions. Its chloro group facilitates Suzuki, Stille, and Buchwald–Hartwig couplings, while the pendant amine and methyl substituents provide orthogonal reactivity for further functionalization. The compound exhibits good bench stability and ease of purification, making it well-suited for iterative synthesis workflows in API development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 38.91
LogP 1.62562
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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4-Chloro-5-methylpyridin-2-amine

CAS No. 1033203-31-4

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