6-Amino-4-chloronicotinonitrile

Name: 6-Amino-4-chloronicotinonitrile
Brand: ChemScene
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CAS No. 670253-38-0
Cat. No. CS-0127673
Purity≥96%
MDL No.None

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Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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6-Amino-4-chloronicotinonitrile|CS-0127673

Structure of 670253-38-0

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General Information

CAS No. 670253-38-0
Cat. No. CS-0127673
Purity ≥96%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄ClN₃
Molecular Weight 153.57
Synonym(s) 6-amino-4-chloro-3-Pyridinecarbonitrile
SMILES NC1=NC=C(C#N)C(Cl)=C1

Description

6-Amino-4-chloronicotinonitrile features a conjugated triad of amino, chloro, and cyano groups on a pyridine core, enabling versatile integration into pharmaceutical scaffolds. The electron-deficient ring facilitates nucleophilic substitution, while the amino group offers direct derivatization potential. This bench-stable compound serves as a key intermediate in agrochemical and medicinal chemistry applications.

Application

6-Amino-4-chloronicotinonitrile serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted pyridine scaffolds through standard coupling and functional group transformation protocols. Its amino and nitrile groups offer orthogonal reactivity, while the chloro substituent facilitates palladium-catalyzed cross-coupling reactions. The compound exhibits good bench stability and is readily purified by recrystallization, supporting its use in scalable API intermediate development.

Safety Information

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GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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Computational Chemistry Data

TPSA 62.7
LogP 1.18888
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Amino-4-chloronicotinonitrile

CAS No. 670253-38-0

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