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Structure of 102878-83-1
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3-Chloroquinolin-8-ol delivers a rigid, electron-deficient quinoline scaffold bearing a strategically positioned hydroxyl group. This configuration enables direct functionalization at the 8-position and enhances solubility in polar solvents. The chloro substituent at C3 supports downstream cross-coupling reactions, while the phenolic OH facilitates hydrogen bonding and metal coordination. Bench-stable under standard conditions, this compound serves as a key intermediate in the synthesis of bioactive heterocycles and ligands for transition metal catalysis.
3-Chloroquinolin-8-ol serves as a versatile building block in medicinal chemistry, enabling efficient construction of quinoline-based scaffolds. Its chlorine and phenolic hydroxyl groups provide orthogonal reactivity for palladium-catalyzed cross-coupling and directed functionalization. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns in API development and target-oriented discovery.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: